Tripeptide-1

What is Tripeptide-1?

Tripeptide-1 is the simple yet powerful trio of amino acids (glycine-histidine-lysine) that becomes a potent regenerative force when combined with copper ions. This small peptide sequence has remarkable affinity for binding copper and delivering it precisely where skin cells can utilize it most effectively. Think of it as a specialized courier service ensuring valuable materials reach exactly the right destination. It's the skincare equivalent of precision infrastructure improvement—targeting resources to the areas of greatest need rather than general distribution. For those seeking improved skin density and firmness with enhanced wound healing capacity, tripeptide-1 offers the fundamental building blocks and delivery system for copper, one of skin's most valuable mineral cofactors for enzyme function, with studies showing improvements in collagen synthesis, elasticity, and barrier recovery, particularly when formulated with stable delivery systems that enhance penetration.

Perfect For

Oily: Neutral effect on oily skin
Dry: Neutral effect on dry skin
Sensitive: Neutral effect on sensitive skin
Combination: Depends on specific formulation and application technique
Mature: Neutral effect on mature skin

Ingredient Interactions

Works well with: hyaluronic acid, niacinamide, antioxidants

Avoid combining with: aha, bha, direct acids, copper peptides with vitamin c

Notes: Works well in hydrating, repairing formulas; some peptides are pH sensitive

References

Strength: Moderate - Some clinical evidence

Key Studies:
• Lupo MP, et al. Journal of Drugs in Dermatology (2007): Study on peptides in dermatology
• Schagen SK. Cosmetics (2017): Review of topical peptides for skin aging
• Robinson LR, et al. International Journal of Cosmetic Science (2005): Research on specific peptides

Mechanisms:
• Signal peptides stimulate collagen, elastin, and other proteins
• Carrier peptides deliver trace elements necessary for wound healing
• Neurotransmitter inhibitor peptides reduce muscle contractions
• Enzyme inhibitor peptides block processes that break down collagen