Tretinoin

What is Tretinoin?

Tretinoin is the prescription-strength cornerstone upon which modern anti-aging skincare was built—the pure retinoic acid that transformed dermatology when its anti-aging benefits were discovered accidentally during acne treatments. This powerful compound binds directly to skin cell receptors without requiring conversion, delivering the most potent retinoid effects possible. Think of it as having a direct line to the CEO instead of working through management layers. It's the skincare equivalent of professional-grade equipment—more powerful than consumer versions but requiring proper training to use without causing damage. For those with significant signs of photoaging, stubborn wrinkles, or texture concerns who are willing to work through an adjustment period, tretinoin offers unparalleled efficacy backed by more clinical studies than any other topical anti-aging ingredient.

Perfect For

Oily: Neutral effect on oily skin
Dry: Neutral effect on dry skin
Sensitive: Neutral effect on sensitive skin
Combination: Depends on specific formulation and application technique
Mature: Neutral effect on mature skin

Ingredient Interactions

Works well with: niacinamide, hyaluronic acid, ceramides, peptides, squalane

Avoid combining with: vitamin c, ascorbic acid, benzoyl peroxide, aha, bha, glycolic acid, salicylic acid

Notes: Can be used with moisturizing ingredients to reduce irritation; avoid using with other active exfoliants to prevent barrier damage

References

Strength: Variable - See literature

Mechanisms:
• Mechanism of action depends on specific ingredient composition