Syn-Ake

What is Syn-Ake?

Syn-Ake is the snake venom-inspired wrinkle smoother—a synthetic tripeptide that mimics the effect of Waglerin-1, a peptide found in temple viper venom that temporarily blocks neuromuscular contractions. This innovative ingredient helps relax facial muscles that cause expression lines to form without the paralysis of actual toxins. Think of it as borrowing the snake's strategy without its harmful intent. It's the skincare equivalent of learning self-defense moves from a martial arts master—adopting effective techniques without the intention to harm. For those seeking significant reduction in expression lines from repeated muscle movements, Syn-Ake offers impressive smoothing effects with studies showing up to 52% reduction in wrinkle depth after 28 days, particularly effective on crow's feet, forehead lines, and frown lines when used consistently, creating a more relaxed appearance without eliminating natural expressiveness.

Perfect For

Oily: Neutral effect on oily skin
Dry: Neutral effect on dry skin
Sensitive: Neutral effect on sensitive skin
Combination: Depends on specific formulation and application technique
Mature: Neutral effect on mature skin

Ingredient Interactions

Works well with: most ingredients

Avoid combining with: depends on specific formulation

Notes: Compatibility depends on product formulation, pH, and concentration

References

Strength: Variable - See literature

Mechanisms:
• Mechanism of action depends on specific ingredient composition