Palmitoyl Tetrapeptide-7

What is Palmitoyl Tetrapeptide-7?

Palmitoyl tetrapeptide-7 is the inflammation-fighting rejuvenator—a synthetic peptide that reduces the production of interleukins, the chemical messengers involved in triggering skin inflammation. This specialized peptide (one half of Matrixyl 3000) helps prevent glycation damage to collagen while calming the chronic low-grade inflammation that accelerates aging. Think of it as a diplomatic peacekeeper that prevents minor conflicts from escalating into damaging wars within your skin. It's the skincare equivalent of preventive medicine—addressing the underlying inflammatory factors that drive aging before visible damage occurs. For those concerned with inflammaging (aging accelerated by chronic inflammation) or sensitivity that prevents use of more aggressive anti-aging ingredients, palmitoyl tetrapeptide-7 offers that perfect combination of gentle action and significant results that improves skin quality without triggering reactivity, making it particularly valuable in comprehensive peptide formulations targeting multiple aging pathways simultaneously.

Perfect For

Oily: Neutral effect on oily skin
Dry: Neutral effect on dry skin
Sensitive: Neutral effect on sensitive skin
Combination: Depends on specific formulation and application technique
Mature: Neutral effect on mature skin

Ingredient Interactions

Works well with: hyaluronic acid, niacinamide, antioxidants

Avoid combining with: aha, bha, direct acids, copper peptides with vitamin c

Notes: Works well in hydrating, repairing formulas; some peptides are pH sensitive

References

Strength: Moderate - Some clinical evidence

Key Studies:
• Lupo MP, et al. Journal of Drugs in Dermatology (2007): Study on peptides in dermatology
• Schagen SK. Cosmetics (2017): Review of topical peptides for skin aging
• Robinson LR, et al. International Journal of Cosmetic Science (2005): Research on specific peptides

Mechanisms:
• Signal peptides stimulate collagen, elastin, and other proteins
• Carrier peptides deliver trace elements necessary for wound healing
• Neurotransmitter inhibitor peptides reduce muscle contractions
• Enzyme inhibitor peptides block processes that break down collagen