Palmitoyl Tetrapeptide-5
What is Palmitoyl Tetrapeptide-5?
Palmitoyl tetrapeptide-5 is the tissue growth factor modulator—a synthetic peptide that helps regulate TGF-β (Transforming Growth Factor beta), one of the key signaling molecules involved in collagen production and organization. This specialized peptide strengthens the dermal-epidermal junction while ensuring collagen is produced in optimal amounts and patterns. Think of it as a skilled supervisor overseeing the construction of a complex building, ensuring materials are used efficiently and structural integrity is maintained. It's the skincare equivalent of quality control in manufacturing—ensuring not just quantity but quality and proper organization of newly produced components. For those concerned with thinning skin and loss of structural integrity rather than just surface wrinkles, palmitoyl tetrapeptide-5 offers targeted support for the critical connection point between skin's upper and lower layers, strengthening the overall architecture for improvement that goes beyond surface appearance to enhance fundamental skin resilience.
Perfect For
Oily: Neutral effect on oily skin
Dry: Neutral effect on dry skin
Sensitive: Neutral effect on sensitive skin
Combination: Depends on specific formulation and application technique
Mature: Neutral effect on mature skin
Ingredient Interactions
Works well with: hyaluronic acid, niacinamide, antioxidants
Avoid combining with: aha, bha, direct acids, copper peptides with vitamin c
Notes: Works well in hydrating, repairing formulas; some peptides are pH sensitive
References
Strength: Moderate - Some clinical evidence
Key Studies:
• Lupo MP, et al. Journal of Drugs in Dermatology (2007): Study on peptides in dermatology
• Schagen SK. Cosmetics (2017): Review of topical peptides for skin aging
• Robinson LR, et al. International Journal of Cosmetic Science (2005): Research on specific peptides
Mechanisms:
• Signal peptides stimulate collagen, elastin, and other proteins
• Carrier peptides deliver trace elements necessary for wound healing
• Neurotransmitter inhibitor peptides reduce muscle contractions
• Enzyme inhibitor peptides block processes that break down collagen