Hexapeptide-9

What is Hexapeptide-9?

Hexapeptide-9 is the collagen-organizing architect—a synthetic peptide that not only stimulates collagen production but actively improves how it's assembled into stronger, more functional fibers. This sophisticated ingredient works by mimicking fragments of type I collagen, signaling fibroblasts to create more structured and organized extracellular matrix components. Think of it as not just increasing building materials but ensuring they're assembled according to the optimal blueprint. It's the skincare equivalent of 3D printing—creating precisely structured replacements rather than generic building blocks. For mature skin concerned with loss of definition and structure beyond surface wrinkles, hexapeptide-9 offers comprehensive remodeling that improves the fundamental architecture of skin, with particular benefits for areas showing significant laxity and loss of contour, helping to restore more defined facial features through improved underlying support structure rather than just surface tightening.

Perfect For

Oily: Neutral effect on oily skin
Dry: Neutral effect on dry skin
Sensitive: Neutral effect on sensitive skin
Combination: Depends on specific formulation and application technique
Mature: Neutral effect on mature skin

Ingredient Interactions

Works well with: hyaluronic acid, niacinamide, antioxidants

Avoid combining with: aha, bha, direct acids, copper peptides with vitamin c

Notes: Works well in hydrating, repairing formulas; some peptides are pH sensitive

References

Strength: Moderate - Some clinical evidence

Key Studies:
• Lupo MP, et al. Journal of Drugs in Dermatology (2007): Study on peptides in dermatology
• Schagen SK. Cosmetics (2017): Review of topical peptides for skin aging
• Robinson LR, et al. International Journal of Cosmetic Science (2005): Research on specific peptides

Mechanisms:
• Signal peptides stimulate collagen, elastin, and other proteins
• Carrier peptides deliver trace elements necessary for wound healing
• Neurotransmitter inhibitor peptides reduce muscle contractions
• Enzyme inhibitor peptides block processes that break down collagen