Adapalene

What is Adapalene?

Adapalene is like the modern, engineered version of tretinoin—a synthetic retinoid designed specifically to reduce irritation while maintaining powerful efficacy. This once-prescription-only ingredient (now available over-the-counter) binds selectively to specific retinoid receptors to minimize side effects while maximizing benefits. Think of it as precision medicine that targets exactly what needs fixing while leaving other processes undisturbed. It's the skincare equivalent of a smart thermostat—delivering the right amount of power exactly where needed rather than blasting the entire system. For those who've struggled with traditional retinoids due to sensitivity but still want effective results, adapalene offers that perfect combination of prescription-level efficacy with significantly improved tolerability that makes consistent use possible even for those with reactive skin.

Perfect For

Oily: Neutral effect on oily skin
Dry: Neutral effect on dry skin
Sensitive: Neutral effect on sensitive skin
Combination: Depends on specific formulation and application technique
Mature: Neutral effect on mature skin

Ingredient Interactions

Works well with: niacinamide, hyaluronic acid, ceramides, peptides, squalane

Avoid combining with: vitamin c, ascorbic acid, benzoyl peroxide, aha, bha, glycolic acid, salicylic acid

Notes: Can be used with moisturizing ingredients to reduce irritation; avoid using with other active exfoliants to prevent barrier damage

References

Strength: Variable - See literature

Mechanisms:
• Mechanism of action depends on specific ingredient composition