Acetyl Tetrapeptide-5

What is Acetyl Tetrapeptide-5?

Acetyl tetrapeptide-5 is the eye area rejuvenator that targets puffiness and fluid retention—a specialized peptide that improves lymphatic drainage while strengthening capillaries to reduce under-eye bags and dark circles. This innovative peptide inhibits glycation damage to collagen while regulating the inflammatory mediators that contribute to fluid accumulation. Think of it as a drainage system engineer who improves both the pipes and the pumps to prevent flooding. It's the skincare equivalent of solving a problem at its source rather than just treating symptoms—addressing the underlying causes of eye area aging rather than temporarily masking them. For those concerned with under-eye puffiness, dark circles, and the general loss of resilience in the delicate eye area, acetyl tetrapeptide-5 offers targeted improvement with studies showing up to 70% reduction in eye bag volume after two months, particularly effective when formulated in lightweight textures that don't cause milia or irritation.

Perfect For

Oily: Neutral effect on oily skin
Dry: Neutral effect on dry skin
Sensitive: Neutral effect on sensitive skin
Combination: Depends on specific formulation and application technique
Mature: Neutral effect on mature skin

Ingredient Interactions

Works well with: hyaluronic acid, niacinamide, antioxidants

Avoid combining with: aha, bha, direct acids, copper peptides with vitamin c

Notes: Works well in hydrating, repairing formulas; some peptides are pH sensitive

References

Strength: Moderate - Some clinical evidence

Key Studies:
• Lupo MP, et al. Journal of Drugs in Dermatology (2007): Study on peptides in dermatology
• Schagen SK. Cosmetics (2017): Review of topical peptides for skin aging
• Robinson LR, et al. International Journal of Cosmetic Science (2005): Research on specific peptides

Mechanisms:
• Signal peptides stimulate collagen, elastin, and other proteins
• Carrier peptides deliver trace elements necessary for wound healing
• Neurotransmitter inhibitor peptides reduce muscle contractions
• Enzyme inhibitor peptides block processes that break down collagen