Acetyl Dipeptide-1 Cetyl Ester

What is Acetyl Dipeptide-1 Cetyl Ester?

Acetyl dipeptide-1 cetyl ester is the calming barrier defender—a specialized peptide that strengthens skin's defenses against environmental aggressors while reducing sensitivity and reactivity. This innovative ingredient works by enhancing the production of β-endorphins in skin cells, creating a natural soothing effect that reduces discomfort while improving tolerance to irritants. Think of it as training your skin's sensory system to have a higher threshold for discomfort before triggering inflammatory responses. It's the skincare equivalent of stress management techniques that increase your ability to handle pressure without overreacting.

For those with sensitive, reactive skin that's easily triggered by products, environmental factors, or procedures, acetyl dipeptide-1 cetyl ester offers both immediate comfort and long-term improvement in skin resilience, making it particularly valuable in products designed for compromised barriers, post-procedure recovery, or conditions characterized by heightened sensitivity like rosacea or eczema-prone skin.

Perfect For

Oily: Neutral effect on oily skin
Dry: Neutral effect on dry skin
Sensitive: Neutral effect on sensitive skin
Combination: Depends on specific formulation and application technique
Mature: Neutral effect on mature skin

Ingredient Interactions

Works well with: hyaluronic acid, niacinamide, antioxidants

Avoid combining with: aha, bha, direct acids, copper peptides with vitamin c

Notes: Works well in hydrating, repairing formulas; some peptides are pH sensitive

References

Strength: Moderate - Some clinical evidence

Key Studies:
• Lupo MP, et al. Journal of Drugs in Dermatology (2007): Study on peptides in dermatology
• Schagen SK. Cosmetics (2017): Review of topical peptides for skin aging
• Robinson LR, et al. International Journal of Cosmetic Science (2005): Research on specific peptides

Mechanisms:
• Signal peptides stimulate collagen, elastin, and other proteins
• Carrier peptides deliver trace elements necessary for wound healing
• Neurotransmitter inhibitor peptides reduce muscle contractions
• Enzyme inhibitor peptides block processes that break down collagen